Selplg Gene Summary [Mouse]
Involved in leukocyte adhesive activation. Acts upstream of or within leukocyte tethering or rolling. Predicted to be located in plasma membrane raft and uropod. Predicted to be active in plasma membrane. Is expressed in brain and thymus primordium. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human SELPLG (selectin P ligand). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Selplg |
| Official Name | selectin, platelet (p-selectin) ligand [Source:MGI Symbol;Acc:MGI:106689] |
| Ensembl ID | ENSMUSG00000048163 |
| Bio databases IDs | |
| Aliases | selectin, platelet (p-selectin) ligand |
| Synonyms | CD162, CLA, HECA452, P-SELECTIN binding GLYCOPROTEIN LIGAND, P-selectin ligand, PSGL-1, selectin, platelet (p-selectin) ligand, selectin P ligand, Selp1, SELPL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Selplg often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- cytoplasmic domain
- ectodomain
- transmembrane domain
- mucin domain
- protein binding
- cytosolic tail domain
- membrane-proximal domain
Pathways
Biological processes and signaling networks where the Selplg gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- fibrosis
- Alzheimer disease
- multiorgan inflammation
- diabetic nephropathy
- CD30 positive anaplastic large cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- androgenic alopecia
- acne
role in cell
- expression in
- migration
- production in
- formation
- formation in
- phosphorylation in
- accumulation
- quantity
- survival
- cell rolling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- cell-cell contacts
- uropod
- membrane rafts
- microvilli
- cell membrane leading edge
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Selplg gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- cellular response to interleukin-6
- leukocyte adhesive activation
- cell adhesion
- leukocyte migration
- leukocyte tethering or rolling
Cellular Component
Where in the cell the gene product is active
- uropod
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- viral receptor activity
- receptor binding