Faah Gene Summary [Mouse]
Enables monoacylglycerol lipase activity. Involved in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission. Is active in glutamatergic synapse. Is expressed in several structures, including brain; ganglia; gut; olfactory epithelium; and renal calyx. Human ortholog(s) of this gene implicated in obesity and substance-related disorder. Orthologous to human FAAH (fatty acid amide hydrolase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Faah |
| Official Name | fatty acid amide hydrolase [Source:MGI Symbol;Acc:MGI:109609] |
| Ensembl ID | ENSMUSG00000034171 |
| Bio databases IDs | |
| Aliases | fatty acid amide hydrolase |
| Synonyms | FAAH-1, Faahl, Fatty acid amide hydrolase, PSAB |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Faah often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- amidase
- phospholipid binding
- lipid binding
- fatty acid amide hydrolase
- acylglycerol lipase
- transmembrane domain
- enzyme
- protein binding
- identical protein binding
- ester bond hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypothermia
- COVID-19
- Alzheimer disease
- preterm birth
- ptosis
- psoriasis
- weight gain
- fatigue
- dyslipidemia
- active ulcerative colitis
role in cell
- migration
- formation
- formation in
- expression in
- cell death
- quantity
- signaling in
- accumulation in
- cell spreading
- injury
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- presynaptic regions
- perinuclear region
- postsynaptic region
- cellular membrane
- endoplasmic reticulum membrane
- Golgi membrane
- growth cone
- neurites
- membrane processes
- microvilli
- filopodia
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Faah gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty acid catabolic process
- monoacylglycerol catabolic process
- positive regulation of vasoconstriction
- arachidonic acid metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoskeleton
- organelle membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- acylglycerol lipase activity
- protein binding
- fatty acid amide hydrolase activity
- amidase activity
- phospholipid binding