Slc39a4 Gene Summary [Mouse]
Enables identical protein binding activity and zinc ion transmembrane transporter activity. Involved in intracellular zinc ion homeostasis. Acts upstream of or within cellular response to zinc ion starvation. Located in apical plasma membrane and recycling endosome membrane. Is expressed in several structures, including alimentary system; early embryo; extraembryonic component; genitourinary system; and integumental system. Used to study acrodermatitis enteropathica. Human ortholog(s) of this gene implicated in acrodermatitis enteropathica. Orthologous to human SLC39A4 (solute carrier family 39 member 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc39a4 |
| Official Name | solute carrier family 39 (zinc transporter), member 4 [Source:MGI Symbol;Acc:MGI:1919277] |
| Ensembl ID | ENSMUSG00000063354 |
| Bio databases IDs | |
| Aliases | solute carrier family 39 (zinc transporter), member 4 |
| Synonyms | 1600025H15Rik, AEZ, AWMS2, solute carrier family 39 member 4, solute carrier family 39 (zinc transporter), member 4, ZIP4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc39a4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- histidine-rich region
- ZIP Zinc transporter
- metal ion binding
- Zinc transporter ZIP4 domain
- zinc ion transporter
- identical protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- acrodermatitis enteropathica
- familial acrodermatitis enteropathica
- immunodeficiency
- serous ovarian adenocarcinoma
- serous ovarian cancer
role in cell
- phosphorylation in
- proliferation
- expression in
- cell division
- sequestration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- perinuclear region
- endosomes
- vesicles
- granules
- apical cell surfaces
- basolateral cell surfaces
- apical membrane
- trans Golgi network
- endosomal membrane
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc39a4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular zinc ion homeostasis
- zinc ion import
- cellular response to zinc ion starvation
- zinc ion transmembrane transport
- cellular cation homeostasis
- bicarbonate transport
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle
- recycling endosome membrane
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- zinc ion binding
- metal ion binding
- zinc ion transmembrane transporter activity