Zdhhc12 Gene Summary [Mouse]
Enables protein-cysteine S-palmitoyltransferase activity. Involved in gephyrin clustering involved in postsynaptic density assembly; peptidyl-L-cysteine S-palmitoylation; and positive regulation of GABAergic synaptic transmission. Located in Golgi apparatus. Is expressed in early conceptus; inner cell mass; and oocyte. Orthologous to human ZDHHC12 (zinc finger DHHC-type palmitoyltransferase 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Zdhhc12 |
| Official Name | zinc finger, DHHC domain containing 12 [Source:MGI Symbol;Acc:MGI:1913470] |
| Ensembl ID | ENSMUSG00000015335 |
| Bio databases IDs | |
| Aliases | zinc finger, DHHC domain containing 12 |
| Synonyms | 1190004A01Rik, DHHC-12, zinc finger, DHHC domain containing 12, zinc finger DHHC-type palmitoyltransferase 12, ZNF400 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zdhhc12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- palmitoyltransferase
- protein-cysteine S-palmitoleyltransferase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- lung adenocarcinoma
- lung adenocarcinoma formation
- eczema
- organismal death
- respiratory disorder
regulated by
- palmitic acid
role in cell
- activation in
- degradation in
- cellular infiltration by
- palmitoylation in
- recruitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- Golgi membrane
- dendritic spines
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zdhhc12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of synaptic transmission, GABAergic
- peptidyl-L-cysteine S-palmitoylation
- gephyrin clustering
- protein palmitoylation
- protein targeting to membrane
- negative regulation of NLRP3 inflammasome complex assembly
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- Golgi apparatus
- Golgi membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein-cysteine S-palmitoleyltransferase activity
- palmitoyltransferase activity