Uaca Gene Summary [Mouse]
Enables transcription regulator inhibitor activity. Involved in negative regulation of canonical NF-kappaB signal transduction and negative regulation of non-canonical NF-kappaB signal transduction. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway; negative regulation of inflammatory response; and positive regulation of protein import into nucleus. Located in several cellular components, including cytosol; nuclear envelope; and perinuclear region of cytoplasm. Part of apoptosome. Is expressed in several structures, including cerebral cortex ventricular layer; genitourinary system; heart; liver; and lung. Used to study hepatocellular carcinoma. Orthologous to human UACA (uveal autoantigen with coiled-coil domains and ankyrin repeats). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Uaca |
| Official Name | uveal autoantigen with coiled-coil domains and ankyrin repeats [Source:MGI Symbol;Acc:MGI:1919815] |
| Ensembl ID | ENSMUSG00000034485 |
| Bio databases IDs | |
| Aliases | uveal autoantigen with coiled-coil domains and ankyrin repeats |
| Synonyms | 2700059D02Rik, NUCLING, RGD1560011, UVEAL AUTOANTIGEN, uveal autoantigen with coiled-coil domains and ankyrin repeats |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Uaca often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mitotic checkpoint protein
- Crescentin protein
- chromosome segregation protein SMC, primarily archaeal type
- Ankyrin repeats (many copies)
- exonuclease SbcC
- rad50
- Synaptonemal complex protein 1 (SCP-1)
- Ankyrin repeats (3 copies)
- Myosin tail
- helix-rich Mycoplasma protein
- protein binding
- Protein of unknown function (DUF3584)
- Ankyrin repeat
- Alpha helical coiled-coil rod protein (HCR)
- chromosome segregation protein SMC, common bacterial type
- RecF/RecN/SMC N terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- neoplasia
- cancer
- prostate cancer
- epithelial cancer
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- lung adenocarcinoma
role in cell
- expression in
- phosphorylation in
- apoptosis
- number
- quantity
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- Nucleus
- apoptosome
- cytosol
- nucleoplasm
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Uaca gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoskeleton
- cytosol
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding