Nkx2-3 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; mononuclear cell differentiation; and saliva secretion. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; branchial arch; skin; and submandibular gland primordium. Orthologous to human NKX2-3 (NK2 homeobox 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nkx2-3 |
| Official Name | NK2 homeobox 3 [Source:MGI Symbol;Acc:MGI:97348] |
| Ensembl ID | ENSMUSG00000044220 |
| Bio databases IDs | |
| Aliases | NK2 homeobox 3 |
| Synonyms | CSX3, NK2.3, NK2 homeobox 3, NKX2.3, NKX2C, NKX4-3, tinman |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nkx2-3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- sequence-specific DNA binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- growth failure
- inflammatory bowel disease
- cachexia
- Crohn disease
- ulcerative colitis
- colorectal cancer
phenotypes
- abnormal Peyer's patch follicle morphology
- abnormal blood vessel morphology
- abnormal cell proliferation
- abnormal crypts of Lieberkuhn morphology
- abnormal duodenum morphology
- abnormal gut-associated lymphoid tissue morphology
- abnormal ileum morphology
- abnormal intestinal epithelium morphology
- abnormal intestinal mucosa morphology
- abnormal intestinal peristalsis
- abnormal intestine morphology
- abnormal jejunum crypts of Lieberkuhn morphology
- abnormal jejunum morphology
- abnormal leukocyte migration
- abnormal marginal zone B cell morphology
- abnormal mesenteric lymph node morphology
- abnormal metallophilic macrophage morphology
- abnormal molar cusp morphology
- abnormal oropharynx morphology
- abnormal small intestinal villus morphology
- abnormal small intestine morphology
- abnormal spleen B cell follicle morphology
- abnormal spleen marginal sinus morphology
- abnormal spleen marginal zone macrophage morphology
- abnormal spleen morphology
- abnormal spleen periarteriolar lymphoid sheath morphology
- abnormal spleen primary B follicle morphology
- abnormal spleen red pulp morphology
- abnormal splenic cell ratio
- abnormal sublingual gland morphology
- abnormal tooth development
- absent marginal zone B cells
- absent spleen
- absent spleen marginal zone
- cachexia
- decreased B cell number
- decreased CD4-positive alpha beta T cell number
- decreased Peyer's patch number
- decreased T cell number
- decreased circulating triglyceride level
- decreased lymphocyte cell number
- decreased molar number
- decreased plasma cell number
- decreased spleen weight
- decreased spleen white pulp amount
- delayed intestine development
- diarrhea
- failure of tooth eruption
- increased enterocyte cell number
- increased leukocyte cell number
- intermingled spleen red and white pulp
- postnatal growth retardation
- postnatal lethality incomplete penetrance
- small Peyer's patches
- small cecum
- small spleen
- spleen atrophy
- steatorrhea
role in cell
- quantity
- expression in
- phosphorylation in
- proliferation
- differentiation
- abnormal morphology
- migration
- number
- growth
- lack
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nkx2-3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gland morphogenesis
- spleen development
- triglyceride metabolic process
- transcription from RNA polymerase II promoter
- lymph node development
- odontogenesis of dentin-containing tooth
- CD4-positive, alpha-beta T cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- leukocyte homeostasis
- post-embryonic digestive tract morphogenesis
- plasma cell differentiation
- Peyer's patch development
- cell differentiation
- leukocyte migration
- regulation of epithelial cell proliferation
- macrophage differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity