Jph4 Gene Summary [Mouse]
Acts upstream of or within several processes, including learning; neuromuscular process controlling balance; and regulation of store-operated calcium entry. Located in dendritic shaft and smooth endoplasmic reticulum. Is expressed in ganglia; hindlimb mesenchyme; nervous system; and retina. Orthologous to human JPH4 (junctophilin 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Jph4 |
| Official Name | junctophilin 4 [Source:MGI Symbol;Acc:MGI:2443113] |
| Ensembl ID | ENSMUSG00000022208 |
| Bio databases IDs | |
| Aliases | junctophilin 4 |
| Synonyms | 9330157P13RIK, AI425998, JP-4, JPHL1, junctophilin 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Jph4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Membrane Occupation and Recognition Nexus motif
- MORN repeat
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endometrial cancer
- infertility condition
- Huntington disease
- colon epithelial cancer
- colon carcinoma
- uterine leiomyoma
- leiomyomatosis
role in cell
- expression in
- activation in
- long-term potentiation
- activation
- plasticity
- transport in
- store-operated calcium influx in
- excitatory postsynaptic potential
- afterhyperpolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum-plasma membrane junction
- cellular membrane
- sarcoplasmic reticulum
- smooth endoplasmatic reticulum
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Jph4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of synaptic plasticity
- regulation of cytokine production
- learning
- regulation of store-operated calcium entry
- neuromuscular process controlling balance
- regulation of ryanodine-sensitive calcium-release channel activity
- calcium ion transport into cytosol
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- dendritic shaft
- smooth endoplasmic reticulum
- junctional sarcoplasmic reticulum membrane
- plasma membrane
- junctional membrane complex
Molecular Function
What the gene product does at the molecular level
- protein binding