Edil3 Gene Summary [Mouse]
Predicted to enable calcium ion binding activity. Acts upstream of or within positive regulation of cell-substrate adhesion. Predicted to be located in extracellular region. Is expressed in several structures, including cartilage; cerebral cortex; heart; skeletal system; and trachea. Orthologous to human EDIL3 (EGF like repeats and discoidin domains 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Edil3 |
| Official Name | EGF-like repeats and discoidin I-like domains 3 [Source:MGI Symbol;Acc:MGI:1329025] |
| Ensembl ID | ENSMUSG00000034488 |
| Bio databases IDs | |
| Aliases | EGF-like repeats and discoidin I-like domains 3 |
| Synonyms | DEL1, EGF like repeats and discoidin domains 3, EGF-like repeats and discoidin I-like domains 3, Sox2-cre, Tg(Sox2-cre)1Amc |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Edil3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Coagulation factor 5/8 C-terminal domain, discoidin domain
- integrin binding
- Human growth factor-like EGF
- RGD motif
- F5/8 type C domain
- EGF_CA
- FA58C
Pathways
Biological processes and signaling networks where the Edil3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- aortic valve calcification
- diabetic nephropathy
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- organismal death
- survival
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- gastric cancer
role in cell
- expression in
- proliferation
- phosphorylation in
- quantity
- apoptosis
- accumulation
- adhesion
- migration
- cellular infiltration by
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Edil3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell-substrate adhesion
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
Molecular Function
What the gene product does at the molecular level
- calcium ion binding
- integrin binding
- extracellular matrix structural constituent