Zswim2 Gene Summary [Mouse]
Enables ubiquitin protein ligase activity. Involved in protein polyubiquitination. Acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors. Orthologous to human ZSWIM2 (zinc finger SWIM-type containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zswim2 |
| Official Name | zinc finger SWIM-type containing 2 [Source:MGI Symbol;Acc:MGI:1919111] |
| Ensembl ID | ENSMUSG00000034552 |
| Bio databases IDs | |
| Aliases | zinc finger SWIM-type containing 2 |
| Synonyms | 1700025P14RIK, 4933437F18Rik, MEX, zinc finger SWIM-type containing 2, zinc finger, SWIM-type containing 2, ZZZ2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zswim2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ZZ
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin protein ligase activity
- ubiquitin-protein transferase activity
- SWIM zinc finger
- enzyme
- Ring finger domain
- protein binding
- RING-like zinc finger
- Zinc finger, C3HC4 type (RING finger)
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zswim2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyubiquitination
- apoptotic process
Molecular Function
What the gene product does at the molecular level
- zinc ion binding