Tktl2 Gene Summary [Mouse]
Predicted to enable thiamine pyrophosphate binding activity and transketolase activity. Predicted to be located in cytoplasm. Orthologous to human TKTL2 (transketolase like 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tktl2 |
| Official Name | transketolase-like 2 [Source:MGI Symbol;Acc:MGI:1921669] |
| Ensembl ID | ENSMUSG00000025519 |
| Bio databases IDs | |
| Aliases | transketolase-like 2 |
| Synonyms | 4933401I19Rik, DKFZP434L1717, RGD1304767, transketolase-like 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tktl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transketolase, pyrimidine binding domain
- TPP_enzymes
- transketolase
- Transketolase, thiamine diphosphate binding domain
- enzyme
- Transketolase, C-terminal domain
- thiamine pyrophosphate-dependent enzyme pyrimidine binding domain
- transketolase, bacterial and yeast
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma formation
- diabetes mellitus
- EGFR mutation positive adenocarcinoma of the lung
- EGFR mutation positive non-small cell lung cancer
- EGFR expression positive non-squamous non-small cell lung cancer
regulated by
- KAT5
- pirinixic acid
- p30II
- diphtheria toxin
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tktl2 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- thiamine pyrophosphate binding
- metal ion binding
- transketolase activity