Bcam Gene Summary [Mouse]
Enables laminin receptor activity. Acts upstream of or within cell adhesion. Located in cell surface and plasma membrane. Is expressed in several structures, including genitourinary system; nervous system; skin; small intestine; and spleen. Orthologous to human BCAM (basal cell adhesion molecule (Lutheran blood group)). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bcam |
| Official Name | basal cell adhesion molecule [Source:MGI Symbol;Acc:MGI:1929940] |
| Ensembl ID | ENSMUSG00000002980 |
| Bio databases IDs | |
| Aliases | basal cell adhesion molecule |
| Synonyms | 1200005K12Rik, AU, basal cell adhesion molecule, basal cell adhesion molecule (Lutheran blood group), CD239, F8/G253, Gplu, LU, LUTHERAN, Lutheran blood group, MSK19 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bcam often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- laminin binding
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- laminin receptor
- protein binding
- transmembrane receptor
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- weight gain
- coronary artery disease
- Alzheimer disease
- proteinuria
- early-onset preeclampsia
- Sweet syndrome
- late-onset preeclampsia
role in cell
- proliferation
- morphology
- phosphorylation in
- migration
- adhesion
- invasion by
- attachment
- cell-cell adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- lateral cell surfaces
- apical cell surfaces
- basolateral cell surfaces
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bcam gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- signal transduction
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- external side of plasma membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- transmembrane signaling receptor activity
- laminin receptor activity
- laminin binding