Ppm1h Gene Summary [Mouse]
Predicted to enable [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity and identical protein binding activity. Predicted to be involved in signal transduction. Is active in glutamatergic synapse. Is expressed in ganglia; liver lobe; spinal cord; and thymus primordium. Orthologous to human PPM1H (protein phosphatase, Mg2+/Mn2+ dependent 1H). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Ppm1h |
| Official Name | protein phosphatase 1H (PP2C domain containing) [Source:MGI Symbol;Acc:MGI:2442087] |
| Ensembl ID | ENSMUSG00000034613 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1H (PP2C domain containing) |
| Synonyms | A430075L18RIK, ARHCL1, C030002B11Rik, KIAA1157, NERPP-2C, protein phosphatase 1H (PP2C domain containing), protein phosphatase, Mg2+/Mn2+ dependent 1H, protein phosphatase, Mg2+/Mn2+ dependent, 1H, URCC2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppm1h often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase
- phosphatase
- protein binding
- Serine/threonine phosphatases, family 2C, catalytic domain
- identical protein binding
- PP2Cc
Pathways
Biological processes and signaling networks where the Ppm1h gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endometriosis
- COVID-19
- male pattern hair loss
- osteoarthritis
- thyroiditis
- colorectal adenoma
- colorectal adenoma formation
role in cell
- loss
- abnormal morphology
- pausing
- loss in
- sequestration in
- pausing in
- axonal transport in
- reversal in
- axonal transport
- reversal
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- Cytoplasm
- nucleoplasm
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ppm1h gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein dephosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mitochondrion
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphoprotein phosphatase activity
- identical protein binding
- protein binding
- myosin phosphatase activity
- [pyruvate dehydrogenase (lipoamide)] phosphatase activity