Cdc25b Gene Summary [Mouse]
Predicted to enable protein kinase binding activity and protein tyrosine phosphatase activity. Acts upstream of or within female meiosis I; oocyte maturation; and positive regulation of protein kinase activity. Located in cytoplasm and nucleus. Is expressed in several structures, including 1-cell stage embryo; cerebral cortex ventricular layer; gonad; placenta; and primitive collecting duct. Orthologous to human CDC25B (cell division cycle 25B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdc25b |
| Official Name | cell division cycle 25B [Source:MGI Symbol;Acc:MGI:99701] |
| Ensembl ID | ENSMUSG00000027330 |
| Bio databases IDs | |
| Aliases | cell division cycle 25B |
| Synonyms | CDC25HU2, cell division cycle 25B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cdc25b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- regulatory domain
- protein kinase binding
- protein-tyrosine-phoshatase
- catalytic domain
- Rhodanese Homology Domain
- protein binding
- Rhodanese-like domain
- RHOD
- phosphorylation site
- M-phase inducer phosphatase
- protein phosphatase
- phosphatase
- Jnk phosphorylation site
Pathways
Biological processes and signaling networks where the Cdc25b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- breast cancer
- gastric cancer
- liver cancer
- epithelial cancer
- non-Hodgkin lymphoma
- non-Hodgkin disease
- bipolar disorder
- hepatocellular carcinoma
- colorectal cancer
role in cell
- expression in
- quantity
- migration
- cell death
- growth
- activation in
- phosphorylation in
- differentiation
- proliferation
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- cytosol
- nucleoplasm
- spindle pole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cdc25b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- oocyte maturation
- G2/M transition of mitotic cell cycle
- positive regulation of cell proliferation
- female meiosis I
- protein phosphorylation
- mitotic cell cycle
- positive regulation of cytokinesis
- positive regulation of mitotic cell cycle
- positive regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- spindle pole
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- phosphoprotein phosphatase activity
- protein binding
- protein tyrosine phosphatase activity