Tmem127 Gene Summary [Mouse]
Predicted to enable small GTPase binding activity. Acts upstream of or within endosome organization and regulation of TOR signaling. Predicted to be located in early endosome and plasma membrane. Predicted to be active in membrane. Is expressed in medulla oblongata basal plate and ventral grey horn. Human ortholog(s) of this gene implicated in pheochromocytoma. Orthologous to human TMEM127 (transmembrane protein 127). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmem127 |
| Official Name | transmembrane protein 127 [Source:MGI Symbol;Acc:MGI:1916720] |
| Ensembl ID | ENSMUSG00000034850 |
| Bio databases IDs | |
| Aliases | transmembrane protein 127 |
| Synonyms | 2310003P10Rik, Hs.355708, RGD1309744, transmembrane protein 127 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmem127 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme binding
- Transmembrane protein 127
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- pheochromocytoma formation
- abdominal paraganglioma formation
- paraganglioma formation
- hereditary cancer-predisposing syndrome
- hereditary paraganglioma-pheochromocytoma syndrome
- rheumatoid arthritis
- malignant peritoneal mesothelioma
- epithelial peritoneal cancer
- mesothelioma formation
regulated by
- TP53
role in cell
- proliferation
- abnormal morphology
- organization
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmem127 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endosome organization
- negative regulation of cell proliferation
- negative regulation of TOR signaling cascade
- regulation of TOR signaling cascade
Cellular Component
Where in the cell the gene product is active
- early endosome
- cytoplasm
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- small GTPase binding