Baz1a Gene Summary [Mouse]
Predicted to enable DNA binding activity. Involved in positive regulation of DNA replication. Located in nuclear chromosome and pericentric heterochromatin. Is expressed in several structures, including central nervous system; early conceptus; and genitourinary system. Orthologous to human BAZ1A (bromodomain adjacent to zinc finger domain 1A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Baz1a |
| Official Name | bromodomain adjacent to zinc finger domain 1A [Source:MGI Symbol;Acc:MGI:1309478] |
| Ensembl ID | ENSMUSG00000035021 |
| Bio databases IDs | |
| Aliases | bromodomain adjacent to zinc finger domain 1A |
| Synonyms | ACF1, B930060C03, BC065123, bromodomain adjacent to zinc finger domain 1A, bromodomain adjacent to zinc finger domain, 1A, cbp146, Gtl5, hACF1, LOC100505185, LOC108353558, WALp1, WCRF180 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Baz1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- DDT domain
- Williams-Beuren syndrome DDT (WSD), D-TOX E motif
- PHD finger superfamily
- protein binding
- WSTF, HB1, Itc1p, MBD9 motif 1
- WAC domain
- Bromodomain
- BAZ domain
- ATP-utilizing chromatin assembly and remodelling N-terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- preeclampsia
- non-small cell lung carcinoma
- periodontitis
- teratozoospermia
- oligozoospermia
- VACTERL with central nervous system malformations
- asthenozoospermia
regulated by
- beta-estradiol
- cholecalciferol
- RUNX1
- peripheral blood neutrophils
- garcinol
- E. coli B4 lipopolysaccharide
role in cell
- apoptosis
- formation
- binding in
- assembly
- mitosis
- remodeling
- abnormal morphology
- function
- sliding
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromosome
- centromeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Baz1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- DNA-dependent DNA replication
- regulation of transcription, DNA-dependent
- regulation of DNA replication
- positive regulation of DNA replication
- nucleosome assembly
- regulation of transcription from RNA polymerase II promoter
- regulation of heterochromatin assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- ACF complex
- nuclear chromosome
- centromeric heterochromatin
- chromatin accessibility complex
Molecular Function
What the gene product does at the molecular level
- histone acetyltransferase activity
- DNA binding
- protein binding
- metal ion binding