Flt3 Gene Summary [Mouse]
Enables several functions, including phosphatidylinositol 3-kinase binding activity; protein tyrosine kinase activity; and ubiquitin protein ligase binding activity. Involved in several processes, including common myeloid progenitor cell proliferation; hemopoiesis; and lymphocyte proliferation. Acts upstream of or within several processes, including cellular response to virus; hematopoietic or lymphoid organ development; and regulation of cytokine production. Located in external side of plasma membrane. Is expressed in several structures, including brain; gubernaculum of male; immune system; retina; and spinal cord. Used to study acute myeloid leukemia and juvenile myelomonocytic leukemia. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); leukemia (multiple); and prostate cancer. Orthologous to human FLT3 (fms related receptor tyrosine kinase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Flt3 |
| Official Name | FMS-like tyrosine kinase 3 [Source:MGI Symbol;Acc:MGI:95559] |
| Ensembl ID | ENSMUSG00000042817 |
| Bio databases IDs | |
| Aliases | FMS-like tyrosine kinase 3 |
| Synonyms | B230315G04, CD135, FIT3, FLK-2, Flt3 receptor, FMS-like tyrosine kinase 3, Fms related receptor tyrosine kinase 3, Ly72, STK1, wmfl |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Flt3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein repeat
- phosphoinositide 3-kinase regulator
- protein-tyrosine kinase
- Protein kinase domain
- kinase insertion domain
- activation loop
- intracellular domain
- vascular endothelial growth factor receptor
- membrane-proximal domain
- Tyrosine kinase, catalytic domain
- transmembrane receptor
- ubiquitin protein ligase binding
- extracellular domain
- Protein kinase (unclassified specificity)
- ligand-dependent nuclear receptor interactor
- amphipathic juxta-membrane motif
- Protein tyrosine and serine/threonine kinase
- immunoglobulin domain
- protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- phosphoinositide 3-kinase binding
- binding protein
- Protein Kinases, catalytic domain
- transmembrane receptor protein tyrosine kinase
- transmembrane domain
- tyrosine kinase domain
- cytokine receptor
Pathways
Biological processes and signaling networks where the Flt3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- head and neck squamous cell cancer
- biliary tract cancer
- metastatic esophageal squamous cell carcinoma
- cancer
- metastatic non-small cell lung cancer
- leukemia
- neoplasia
- papillary thyroid cancer
- thyroid gland neoplasm
- hematologic cancer
role in cell
- apoptosis
- expression in
- activation in
- proliferation
- production in
- differentiation
- activation
- cell death
- growth
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- membrane surface
- cellular membrane
- Endoplasmic Reticulum
- plasma membrane extracellular face
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Flt3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- peptidyl-tyrosine phosphorylation
- multicellular organismal development
- hemopoiesis
- positive regulation of cell proliferation
- protein autophosphorylation
- positive regulation of tyrosine phosphorylation of STAT protein
- cytokine-mediated signaling pathway
- myeloid progenitor cell differentiation
- dendritic cell differentiation
- positive regulation of kinase activity
- B cell differentiation
- vascular endothelial growth factor signaling pathway
- transmembrane receptor protein tyrosine kinase signaling pathway
- regulation of apoptotic process
- positive regulation of MAPK cascade
- leukocyte homeostasis
- lymphocyte proliferation
- pro-B cell differentiation
- cellular response to glucocorticoid stimulus
- cellular response to cytokine stimulus
- common myeloid progenitor cell proliferation
- organ regeneration
- response to organic nitrogen
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- endoplasmic reticulum
- receptor complex
- endosome membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- growth factor binding
- protein tyrosine kinase activity
- protein binding
- transmembrane receptor protein tyrosine kinase activity
- vascular endothelial growth factor-activated receptor activity
- cytokine receptor activity
- glucocorticoid receptor binding