Eva1a Gene Summary [Mouse]
Acts upstream of or within several processes, including TOR signaling; cardiac left ventricle morphogenesis; and connective tissue replacement. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Is expressed in foot; hand; left lung; renal calyx; and right lung. Orthologous to human EVA1A (eva-1 homolog A, regulator of programmed cell death). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eva1a |
| Official Name | eva-1 homolog A (C. elegans) [Source:MGI Symbol;Acc:MGI:2385247] |
| Ensembl ID | ENSMUSG00000035104 |
| Bio databases IDs | |
| Aliases | eva-1 homolog A (C. elegans) |
| Synonyms | eva-1 homolog A, regulator of programmed cell death, FAM176A, FLJ13391, LOC102547494, RGD1559797, TMEM166 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eva1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FAM176 family
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gout
- androgenic alopecia
- lung adenocarcinoma formation
- tinnitus
- Huntington disease
- EGFR mutation positive adenocarcinoma of the lung
- EGFR mutation positive non-small cell lung cancer
- EGFR expression positive non-squamous non-small cell lung cancer
role in cell
- apoptosis
- autophagy by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eva1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagy
- apoptotic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- intracellular membrane-bounded organelle
- plasma membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- protein binding