Shc4 Gene Summary [Mouse]
Enables protein domain specific binding activity and receptor tyrosine kinase binding activity. Acts upstream of or within several processes, including apoptotic process; positive regulation of cell population proliferation; and stem cell differentiation. Predicted to be located in postsynaptic membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; heart; sensory organ; and skin. Orthologous to human SHC4 (SHC adaptor protein 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Shc4 |
| Official Name | SHC (Src homology 2 domain containing) family, member 4 [Source:MGI Symbol;Acc:MGI:2655364] |
| Ensembl ID | ENSMUSG00000035109 |
| Bio databases IDs | |
| Aliases | SHC (Src homology 2 domain containing) family, member 4 |
| Synonyms | 6230417E10Rik, 9930029B02Rik, Gm685, LOC688081, RaLP, RGD1309182, SHC adaptor protein 4, SHCD, SHC (Src homology 2 domain containing) family, member 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Shc4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- receptor tyrosine kinase binding
- protein domain specific binding
- Src homology 2 (SH2) domain
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glioma formation
- schizophrenia
- non-insulin-dependent diabetes mellitus
- major depression
- melanoma
- melanoma cancer
- glioma
- eating disorder
- metastatic melanoma
- metastatic melanoma cancer
role in cell
- proliferation
- differentiation
- apoptosis
- phosphorylation in
- binding in
- healing
- migration
- tyrosine phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular space
- neuromuscular junctions
- motor endplates
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Shc4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- stem cell differentiation
- positive regulation of cell proliferation
- apoptotic process
- regulation of gene expression
- transmembrane receptor protein tyrosine kinase signaling pathway
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- postsynaptic membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- receptor tyrosine kinase binding