Garem1 Gene Summary [Mouse]
Predicted to enable proline-rich region binding activity. Acts upstream of or within positive regulation of ERK1 and ERK2 cascade. Is expressed in central nervous system; heart; lung; metanephros; and skeletal musculature. Orthologous to human GAREM1 (GRB2 associated regulator of MAPK1 subtype 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Garem1 |
| Official Name | GRB2 associated regulator of MAPK1 subtype 1 [Source:MGI Symbol;Acc:MGI:2685790] |
| Ensembl ID | ENSMUSG00000042680 |
| Bio databases IDs | |
| Aliases | GRB2 associated regulator of MAPK1 subtype 1 |
| Synonyms | C18orf11, D14Mgi27, FAM59A, GAREM, Gm944, GRB2 associated regulator of MAPK1 subtype 1, LOC100364285, mKIAA4238, RGD1562080 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Garem1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cell-cycle sustaining, positive selection,
- SAM (Sterile alpha motif )
- protein binding
- proline rich domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- breast carcinoma
- lung adenocarcinoma
- lung adenocarcinoma formation
- neoplastic cell transformation
- estrogen receptor-negative breast cancer
- rotator cuff injury
- metabolic disorder
- infection by HIV-1
role in cell
- proliferation
- activation in
- binding in
- crizotinib sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Garem1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell division
- epidermal growth factor receptor signaling pathway
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of cell proliferation
- cellular response to epidermal growth factor stimulus
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- proline-rich region binding
- protein binding