Hacd2 Gene Summary [Mouse]
Predicted to enable enzyme binding activity and very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity. Predicted to be involved in fatty acid elongation; sphingolipid biosynthetic process; and very long-chain fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in tibialis anterior. Orthologous to human HACD2 (3-hydroxyacyl-CoA dehydratase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hacd2 |
| Official Name | 3-hydroxyacyl-CoA dehydratase 2 [Source:MGI Symbol;Acc:MGI:1918007] |
| Ensembl ID | ENSMUSG00000035376 |
| Bio databases IDs | |
| Aliases | 3-hydroxyacyl-CoA dehydratase 2 |
| Synonyms | 3-hydroxyacyl-CoA dehydratase 2, 6330408J20Rik, AI481689, Hcad2, LOC201562, LOC690040, Protein tyrosin phosphatase-like member b, PTPLB |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hacd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3-hydroxyacyl-CoA dehydratase
- phosphatase
- enzyme binding
- protein binding
- Protein tyrosine phosphatase-like protein, PTPLA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
regulates
- 3-hydroxy acyl coenzyme a
- trans-2,3-dehydroacyl-coenzyme A
- fatty acid
- d18:1/18:0 beta-hydroxy ceramide
- sphingolipid
- very long chain fatty acid
role in cell
- morphology
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hacd2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- long-chain fatty-acyl-CoA biosynthetic process
- very long-chain fatty acid biosynthetic process
- fatty acid elongation
- sphingolipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- 3-hydroxyacyl-CoA dehydratase activity
- protein binding
- protein tyrosine phosphatase activity
- enzyme binding