Pdk3 Gene Summary [Mouse]
Predicted to enable ATP binding activity and pyruvate dehydrogenase (acetyl-transferring) kinase activity. Predicted to be involved in several processes, including intracellular signal transduction; peptidyl-serine phosphorylation; and regulation of small molecule metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked dominant 6. Orthologous to human PDK3 (pyruvate dehydrogenase kinase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pdk3 |
| Official Name | pyruvate dehydrogenase kinase, isoenzyme 3 [Source:MGI Symbol;Acc:MGI:2384308] |
| Ensembl ID | ENSMUSG00000035232 |
| Bio databases IDs | |
| Aliases | pyruvate dehydrogenase kinase, isoenzyme 3 |
| Synonyms | 2610001M10Rik, CMTX6, GS1-358P8.4, PDHK3, pyruvate dehydrogenase kinase 3, pyruvate dehydrogenase kinase, isoenzyme 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pdk3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
- protein serine/threonine kinase
- protein kinase
- Histidine kinase-like ATPase domain
- lipoyl-binding pocket
- [pyruvate dehydrogenase (lipoamide)] kinase
- ATP binding
- protein binding
- Histidine kinase-like ATPases
- Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
Pathways
Biological processes and signaling networks where the Pdk3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- insomnia
- obesity
- diabetic nephropathy
- Huntington disease
- Charcot-Marie-Tooth disease X-linked dominant type 6
role in cell
- response by
- mitochondrial respiration in
- ploidy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pdk3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of glucose metabolic process
- cellular response to fatty acid
- regulation of reactive oxygen species metabolic process
- peptidyl-serine phosphorylation
- protein phosphorylation
- peroxisome proliferator activated receptor signaling pathway
- regulation of acetyl-CoA biosynthetic process from pyruvate
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- nucleolus
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein kinase activity
- protein serine/threonine kinase activity
- pyruvate dehydrogenase (acetyl-transferring) kinase activity