Gfm2 Gene Summary [Mouse]
Predicted to enable GTPase activity. Predicted to be involved in mitochondrial translation and ribosome disassembly. Located in mitochondrion. Is expressed in brain; dorsal root ganglion; liver lobe; spinal cord; and thymus primordium. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 39. Orthologous to human GFM2 (GTP dependent ribosome recycling factor mitochondrial 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gfm2 |
| Official Name | G elongation factor, mitochondrial 2 [Source:MGI Symbol;Acc:MGI:2444783] |
| Ensembl ID | ENSMUSG00000021666 |
| Bio databases IDs | |
| Aliases | G elongation factor, mitochondrial 2 |
| Synonyms | 6530419G12Rik, A930009M04RIK, EFG2, EF-G2mt, Elongation factor G2, G elongation factor, mitochondrial 2, GTP dependent ribosome recycling factor mitochondrial 2, hEFG2, mEF-G 2, MRRF2, MST027, MSTP027, RGD1309854, RRF, RRF2, RRF2mt |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gfm2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- elongation factor 4
- Elongation Factor G, domain III
- Domain III of Elongation factor G (EF-G) and related proteins
- GTPase
- translation elongation factor EF-G
- enzyme
- protein binding
- Elongation factor Tu domain 2
- EFG_like_IV
- Elongation_Factor_C
- Domain II of Elongation factor Tu (EF-Tu)-like proteins
- small GTP-binding protein domain
- Elongation factor G C-terminus
- elongation factor G-like protein
- translation elongation factor aEF-2
- Elongation factor Tu GTP binding domain
- P-loop containing Nucleoside Triphosphate Hydrolases
- Elongation factor G, domain IV
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- squamous cell lung cancer
- neoplasia
- combined oxidative phosphorylation deficiency 39
- Leigh syndrome
- mitochondrial disorder
- lung squamous cell carcinoma
- lung adenocarcinoma
- lung adenocarcinoma formation
role in cell
- expression in
- cell death
- growth
- recycling
- mitochondrial respiration in
- disassembly
- josamycin sensitivity
- translation in
- recycling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gfm2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ribosome disassembly
- mitochondrial translational termination
- mitochondrial translation
- mitochondrial translational elongation
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- translation elongation factor activity
- GTPase activity