Helq Gene Summary [Mouse]
Predicted to enable single-stranded 3'-5' DNA helicase activity. Involved in positive regulation of double-strand break repair via homologous recombination. Predicted to be part of single-stranded DNA-dependent ATP-dependent DNA helicase complex. Predicted to be active in nucleus and site of DNA damage. Orthologous to human HELQ (helicase, POLQ like). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Helq |
| Official Name | helicase, POLQ-like [Source:MGI Symbol;Acc:MGI:2176740] |
| Ensembl ID | ENSMUSG00000035266 |
| Bio databases IDs | |
| Aliases | helicase, POLQ-like |
| Synonyms | AU021725, D430018E21Rik, HEL308, helicase, POLQ-like, LOC289471 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Helq often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- single-stranded DNA dependent ATP dependent DNA helicase
- Helix-hairpin-helix domain
- DEAD/DEAH box helicase
- helicase superfamily c-terminal domain
- enzyme
- helix-turn-helix domain
- protein binding
- Helicase conserved C-terminal domain
- DNA helicase
- Type III restriction enzyme, res subunit
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- lymphoma
- lung cancer
- invasive breast cancer
- breast cancer
- gastric adenocarcinoma
- non-metastatic breast cancer
- infiltrating ductal breast carcinoma
- locally advanced breast cancer
- T-cell lymphoblastic lymphoma
regulated by
- pexidartinib
- RPA1
- dGTP
- dATP
- guanosine triphosphate
- D-alpha-hydroxyglutarate
- adenosine triphosphate
- epirubicin
- CTP
- UTP
regulates
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Helq gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA double-strand break processing involved in repair via single-strand annealing
- DNA duplex unwinding
- double-strand break repair via homologous recombination
- double-strand break repair via synthesis-dependent strand annealing
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- DNA binding
- protein binding