Rad51c Gene Summary [Mouse]
Enables crossover junction DNA endonuclease activity. Involved in telomere maintenance via recombination. Acts upstream of or within female meiosis sister chromatid cohesion; meiosis I; and spermatogenesis. Located in nucleus. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group O and hereditary breast ovarian cancer syndrome. Orthologous to human RAD51C (RAD51 paralog C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rad51c |
| Official Name | RAD51 paralog C [Source:MGI Symbol;Acc:MGI:2150020] |
| Ensembl ID | ENSMUSG00000007646 |
| Bio databases IDs | |
| Aliases | RAD51 paralog C |
| Synonyms | BROVCA3, FANCO, R51H3, RAD51L2, RAD51 paralog C, RGD1563765 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rad51c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- crossover junction endoribonuclease
- DNA repair and recombination protein RadB
- DNA repair and recombination protein RadA
- meiotic recombinase Dmc1
- DNA secondary structure binding
- Rad51
- enzyme
- protein binding
- DNA repair protein RAD51
- P-loop containing Nucleoside Triphosphate Hydrolases
- DNA binding
- AAA domain
Pathways
Biological processes and signaling networks where the Rad51c gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric cancer
- epithelial cancer
- breast cancer
- epithelial neoplasia
- cancer
- Fanconi anemia group O
- ovarian cancer
- RAD51C-related disorder
- susceptibility to familial breast-ovarian cancer type 3
- hereditary cancer-predisposing syndrome
role in cell
- growth
- binding in
- phosphorylation in
- expression in
- activation in
- synthesis in
- formation
- formation in
- cell death
- senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cell junction
- intracellular membrane-bounded organelle
- Cytoplasm
- perinuclear region
- Mitochondria
- cytosol
- nucleoplasm
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rad51c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- sister chromatid cohesion
- meiotic DNA recombinase assembly
- reciprocal meiotic recombination
- female meiosis sister chromatid cohesion
- spermatogenesis
- male meiosis I
- double-strand break repair via homologous recombination
- DNA recombination
- telomere maintenance via recombination
- positive regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- Rad51B-Rad51C-Rad51D-XRCC2 complex
- replication fork
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- Rad51C-XRCC3 complex
- intracellular membrane-bounded organelle
- mitochondrion
- cell junction
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- ATP binding
- protein binding
- four-way junction DNA binding
- crossover junction endodeoxyribonuclease activity