Atr Gene Summary [Mouse]
Enables protein kinase activity. Involved in positive regulation of telomere maintenance via telomerase and replication fork processing. Acts upstream of or within several processes, including DNA damage checkpoint signaling; embryo implantation; and protein phosphorylation. Located in XY body and male germ cell nucleus. Part of ATR-ATRIP complex. Is active in GABA-ergic synapse and postsynapse. Is extrinsic component of synaptic vesicle membrane. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; eye; and gonad. Used to study Seckel syndrome. Human ortholog(s) of this gene implicated in Seckel syndrome 1; adenoid cystic carcinoma; colon cancer; lung cancer; and pancreatic cancer. Orthologous to human ATR (ATR serine/threonine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Atr |
| Official Name | ataxia telangiectasia and Rad3 related [Source:MGI Symbol;Acc:MGI:108028] |
| Ensembl ID | ENSMUSG00000032409 |
| Bio databases IDs | |
| Aliases | ataxia telangiectasia and Rad3 related |
| Synonyms | ataxia telangiectasia and Rad3 related, Ataxia-telangiectasia-like, ATR serine/threonine kinase, FCTCS, FRP1, LOC100365674, LOC367198, LOC684113, MEC1, SCKL, SCKL1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PI3K binding domain
- protein serine/threonine kinase
- ATM/ATR homologous domain
- leucine rich domain
- protein kinase
- Phosphatidylinositol 3- and 4-kinase
- ATM-like domain
- catalytic domain
- UME (NUC010) domain
- PI3K catalytic domain
- leucine zipper domain
- enzyme
- protein binding
- FATC domain
- kinase
- kinase domain
- FAT domain
- Phosphoinositide 3-kinase, catalytic domain
- binding protein
- Protein Kinases, catalytic domain
Pathways
Biological processes and signaling networks where the Atr gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Aryl Hydrocarbon Receptor Signaling
- ATM Signaling
- Autophagy
- Cyclins and Cell Cycle Regulation
- DNA damage-induced 14-3-3σ Signaling
- GADD45 Signaling
- Hereditary Breast Cancer Signaling
- Molecular Mechanisms of Cancer
- p53 Signaling
- Role of BRCA1 in DNA Damage Response
- Role of CHK Proteins in Cell Cycle Checkpoint Control
- UVC-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- lung adenocarcinoma
- lung adenocarcinoma formation
- Alzheimer disease
- Seckel syndrome 1
- prostate cancer
- Hutchinson-Gilford progeria syndrome
- glioblastoma
- glioblastoma cancer
role in cell
- activation in
- apoptosis
- expression in
- phosphorylation in
- cell death
- binding in
- activity
- cell cycle progression
- quantity
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin fraction
- postsynaptic region
- cellular membrane
- Golgi Apparatus
- nuclear foci
- chromosome
- nucleoplasm
- nucleoli
- nuclear bodies
- sex chromatin
- nuclear envelope
- synapse
- PML nuclear bodies
- synaptonemal complexes
- telomeres
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- replicative senescence
- regulation of cellular response to heat
- DNA replication
- protein autophosphorylation
- response to xenobiotic stimulus
- response to mechanical stimulus
- double-strand break repair
- chromatin remodeling
- regulation of double-strand break repair
- response to arsenic-containing substance
- cellular response to UV
- replication fork processing
- positive regulation of DNA damage response, signal transduction by p53 class mediator
- telomere maintenance
- negative regulation of DNA replication
- response to DNA damage stimulus
- nuclear envelope disassembly
- nucleobase-containing compound metabolic process
- DNA damage checkpoint
- cellular response to gamma radiation
- protein localization to chromosome, telomeric region
- positive regulation of telomere maintenance via telomerase
- peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nucleus
- chromosome, telomeric region
- PML body
- ATR-ATRIP complex
- Golgi apparatus
- chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- MutSalpha complex binding
- DNA binding
- ATP binding
- MutLalpha complex binding
- protein binding
- protein kinase activity
- histone kinase activity (H2A-S139 specific)
- protein serine/threonine kinase activity