G2e3 Gene Summary [Mouse]
Enables ubiquitin protein ligase activity. Acts upstream of or within blastocyst development; negative regulation of intrinsic apoptotic signaling pathway; and protein polyubiquitination. Predicted to be located in Golgi apparatus and cytosol. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; epithelium; limb; liver; and male reproductive gland or organ. Orthologous to human G2E3 (G2/M-phase specific E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | G2e3 |
| Official Name | G2/M-phase specific E3 ubiquitin ligase [Source:MGI Symbol;Acc:MGI:2444298] |
| Ensembl ID | ENSMUSG00000035293 |
| Bio databases IDs | |
| Aliases | G2/M-phase specific E3 ubiquitin ligase |
| Synonyms | 6030408C04Rik, 9030416F18, D930034K21Rik, FLJ20333, G2/M-phase specific E3 ubiquitin ligase, G2/M-phase specific E3 ubiquitin protein ligase, KIAA1333, mKIAA1333, PHF7B, RGD1310263 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse G2e3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HECTc
- PHD-like zinc-binding domain
- ubiquitin protein ligase activity
- Domain Homologous to E6-AP Carboxyl Terminus with
- PHD finger superfamily
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Golgi Apparatus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse G2e3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- intracellular membrane-bounded organelle
- cytosol
- Golgi apparatus
- nucleolus
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- metal ion binding