Nup37 Gene Summary [Mouse]

Predicted to be involved in nucleocytoplasmic transport. Predicted to be located in nuclear envelope and nucleoplasm. Predicted to be part of nuclear pore outer ring. Predicted to colocalize with kinetochore. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and hemolymphoid system. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 24. Orthologous to human NUP37 (nucleoporin 37). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Nup37
Official Name
nucleoporin 37 [Source:MGI Symbol;Acc:MGI:1919964]
Ensembl ID
ENSMUSG00000035351
Bio databases IDs NCBI: 69736 Ensembl: ENSMUSG00000035351
Aliases nucleoporin 37
Synonyms 2410003L22Rik, 2810039M17Rik, MCPH24, nucleoporin 37, p37
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nup37 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • WD40 repeats
  • WD domain, G-beta repeat
  • protein binding
  • transporter

Pathways

Biological processes and signaling networks where the Nup37 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • colon cancer
  • autosomal recessive primary microcephaly 24
  • colorectal adenoma
  • colorectal adenoma formation
regulated by
  • beta-estradiol
  • TP53
  • ORAI1
  • PTEN
  • thapsigargin
  • calcitriol
  • phorbol 12,13-dibutyrate
  • Caco2 cells
  • SMAD4
  • Jurkat E6.1 cells

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • metaphase plate
  • cytosol
  • nuclear pores
  • inner nuclear membrane
  • nucleoplasm
  • nuclear rim
  • nuclear envelope
  • kinetochores

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Nup37 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • cell division
  • nucleocytoplasmic transport
  • protein transport
  • chromosome segregation
  • mRNA transport

Cellular Component

Where in the cell the gene product is active
  • nuclear envelope
  • nucleus
  • Nup107-160 complex
  • cytosol
  • kinetochore
  • nuclear pore
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.