Orai1 Gene Summary [Mouse]
Enables store-operated calcium channel activity. Involved in ligand-gated ion channel signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; and positive regulation of insulin secretion. Acts upstream of or within calcium ion import; mammary gland epithelium development; and store-operated calcium entry. Located in basolateral plasma membrane. Is active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and skin. Human ortholog(s) of this gene implicated in immunodeficiency 9 and tubular aggregate myopathy 2. Orthologous to human ORAI1 (ORAI calcium release-activated calcium modulator 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Orai1 |
| Official Name | ORAI calcium release-activated calcium modulator 1 [Source:MGI Symbol;Acc:MGI:1925542] |
| Ensembl ID | ENSMUSG00000049686 |
| Bio databases IDs | |
| Aliases | ORAI calcium release-activated calcium modulator 1 |
| Synonyms | AC140062.1, CRAC, CRACM1, D730049H07Rik, FLJ14466, IMD9, ORAI calcium release-activated calcium modulator 1, ORAT1, RGD1311873, Soc channel, TAM2, TMEM142A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Orai1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- intracellular loop
- calcium channel
- store-operated calcium channel
- extracellular loop
- protein binding
- identical protein binding
- ion channel
- Mediator of CRAC channel activity
Pathways
Biological processes and signaling networks where the Orai1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- tubular aggregate myopathy type 2
- major depression
- cervical cancer
- anhedonia
- immune dysfunction with T-cell inactivation due to calcium entry defect type 1
- acute lung injury
- mechanical hypersensitivity
- multiple sclerosis
- tubular aggregate myopathy
role in cell
- proliferation
- phosphorylation in
- binding in
- apoptosis
- expression in
- activation in
- growth
- loss
- quantity
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cell periphery
- cellular membrane
- Golgi Apparatus
- cytosol
- basolateral membrane
- growth cone
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Orai1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- store-operated calcium entry
- calcium ion import
- positive regulation of calcium ion transport
- calcium ion transmembrane transport
- mammary gland epithelium development
- adaptive immune response
- positive regulation of adenylate cyclase activity
- phospholipase C-activating G-protein coupled receptor signaling pathway
- regulation of calcium ion transport
- positive regulation of insulin secretion
Cellular Component
Where in the cell the gene product is active
- calcium channel complex
- membrane raft
- membrane
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- store-operated calcium channel activity
- identical protein binding
- calmodulin binding
- protein binding
- calcium channel activity