Cox18 Gene Summary [Mouse]
Predicted to enable membrane insertase activity. Predicted to be involved in mitochondrial cytochrome c oxidase assembly and protein insertion into mitochondrial inner membrane from matrix. Located in mitochondrion. Orthologous to human COX18 (cytochrome c oxidase assembly factor COX18). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cox18 |
| Official Name | cytochrome c oxidase assembly protein 18 [Source:MGI Symbol;Acc:MGI:2448532] |
| Ensembl ID | ENSMUSG00000035505 |
| Bio databases IDs | |
| Aliases | cytochrome c oxidase assembly protein 18 |
| Synonyms | COX18HS, cytochrome c oxidase assembly factor COX18, cytochrome c oxidase assembly protein 18, OXA1L2, RGD1559547 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cox18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PRK00145
- membrane protein insertase, YidC/Oxa1 family, C-terminal domain
- Five transmembrane core domain of YidC/Oxa1/Alb3 protein family of insertases
- 60Kd inner membrane protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cox18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein insertion into mitochondrial membrane from inner side
- mitochondrial respiratory chain complex IV assembly
- protein insertion into mitochondrial membrane
- respiratory chain complex IV assembly
Cellular Component
Where in the cell the gene product is active
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- membrane insertase activity
- protein binding