Nlrx1 Gene Summary [Mouse]
Predicted to enable ATP binding activity. Acts upstream of or within negative regulation of canonical NF-kappaB signal transduction; negative regulation of cytokine production; and regulation of defense response. Located in mitochondrion. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human NLRX1 (NLR family member X1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nlrx1 |
| Official Name | NLR family member X1 [Source:MGI Symbol;Acc:MGI:2429611] |
| Ensembl ID | ENSMUSG00000032109 |
| Bio databases IDs | |
| Aliases | NLR family member X1 |
| Synonyms | CLR11.3, DLNB26, NLR family member X1, NOD26, NOD5, NOD9, RGD1311293 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nlrx1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleotide-binding domain
- leucine-rich repeat
- nucleic acid binding domain
- protein binding
- NACHT domain
- X domain
- P-loop containing Nucleoside Triphosphate Hydrolases
- nucleotide binding oligomerization domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- colorectal cancer
- septic shock
- colitis-associated cancer
- dextran sodium sulfate-induced colitis
- metastasis
- weight loss
- cervical cancer
- advanced cancer
regulated by
- lipopolysaccharide
- TP53
- TNF
- Mef cells
- ammonium
- 293t cells
- 2-deoxyglucose
- SYK/ZAP
- Large T Antigen
- NX-13
role in cell
- apoptosis
- activation in
- expression in
- proliferation
- quantity
- production in
- number
- migration
- cell viability
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- filamentous network
- Plasma Membrane
- Mitochondria
- cytosol
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nlrx1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of interleukin-6 production
- innate immune response
- negative regulation of inflammatory response
- negative regulation of macrophage cytokine production
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- negative regulation of innate immune response
- negative regulation of RIG-I signaling pathway
- negative regulation of interferon-beta production
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- cytosol
- mitochondrial outer membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding