Vnn1 Gene Summary [Mouse]
Enables pantetheine hydrolase activity. Involved in several processes, including coenzyme A catabolic process; positive regulation of T cell differentiation in thymus; and positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; facial bone primordium; genitourinary system; nervous system; and respiratory system. Orthologous to human VNN1 (vanin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vnn1 |
| Official Name | vanin 1 [Source:MGI Symbol;Acc:MGI:108395] |
| Ensembl ID | ENSMUSG00000037440 |
| Bio databases IDs | |
| Aliases | vanin 1 |
| Synonyms | HDLCQ8, Tiff66, V-1, Vanin-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vnn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Vanin C-terminal domain
- lipid binding
- binding protein
- nitrilase
- pantetheinase
- linear amide carbon-nitrogen bond hydrolase
- enzyme
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- fibrosis
- psoriasis
- sepsis
- hepatocellular carcinoma
- liver cancer
- acute coronary syndrome
- septic shock
- streptozotocin-induced diabetic nephropathy
- multicentric carpotarsal osteolysis syndrome
role in cell
- expression in
- apoptosis
- quantity
- differentiation
- activation
- chondrogenesis
- replication in
- senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- secretory granule membrane
- lysosome membrane
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vnn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chronic inflammatory response
- response to oxidative stress
- inflammatory response
- positive regulation of T cell differentiation in thymus
- acute inflammatory response
- innate immune response
- pantothenate metabolic process
- coenzyme A catabolic process
Cellular Component
Where in the cell the gene product is active
- membrane
- extracellular region
- azurophil granule membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- pantetheine hydrolase activity