Pcolce2 Gene Summary [Mouse]
Predicted to enable collagen binding activity; heparin binding activity; and peptidase activator activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Located in collagen-containing extracellular matrix. Is expressed in several structures, including branchial arch; jaw; limb; nasal cavity epithelium; and skeleton. Orthologous to human PCOLCE2 (procollagen C-endopeptidase enhancer 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pcolce2 |
| Official Name | procollagen C-endopeptidase enhancer 2 [Source:MGI Symbol;Acc:MGI:1923727] |
| Ensembl ID | ENSMUSG00000015354 |
| Bio databases IDs | |
| Aliases | procollagen C-endopeptidase enhancer 2 |
| Synonyms | 2400001O18Rik, PCPE2, procollagen C-endopeptidase enhancer 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pcolce2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NTR_like
- CUB
- collagen binding
- protein binding
- protease activator
- heparin binding
- NTR domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- kidney disease
- colon adenocarcinoma
- flu
- colon epithelial cancer
- febrile seizure
- tuberculosis
- diabetic nephropathy
- aortic valve calcification
- septic shock
role in cell
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pcolce2 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- peptidase activator activity
- collagen binding
- heparin binding