Midn Gene Summary [Mouse]

This gene encodes a protein that contains an ubiquitin-like domain. This protein may be involved in the regulation of brain development as inferred by its high expression level in the embryonic midbrain. This protein has been found to negatively regulate glucokinase activity and insulin secretion in pancreatic beta cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Details

Type
Protein Coding
Official Symbol
Midn
Official Name
midnolin [Source:MGI Symbol;Acc:MGI:1890222]
Ensembl ID
ENSMUSG00000035621
Bio databases IDs NCBI: 59090 Ensembl: ENSMUSG00000035621
Aliases midnolin
Synonyms 3000003C15Rik, midnolin, Stx
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Midn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • kinase binding
  • Ubl1_cv_Nsp3_N-like
  • protein binding
  • ubiquitin-like domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • nephrosis
regulated by
  • D-glucose
  • Bacillus anthracis strain Sterne
  • HIF1A-AS1
  • GLI1
  • CREB1
  • CREM
  • cocaine
regulates
role in cell
  • binding in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • Cytoplasm
  • cytoplasmic particles
  • cytosol
  • nucleoli

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Midn gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • negative regulation of glucokinase activity
  • negative regulation of insulin secretion
  • proteasomal ubiquitin-independent protein catabolic process

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • cytoplasm
  • cytosol
  • nucleolus

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • kinase binding
  • binding, bridging

Gene-Specific Assays for Results You Can Trust

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