Slc1a5 Gene Summary [Mouse]
Enables L-aspartate transmembrane transporter activity and neutral L-amino acid transmembrane transporter activity. Involved in L-aspartate import across plasma membrane and transport across blood-brain barrier. Located in basal plasma membrane. Is active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; liver; and respiratory system. Orthologous to human SLC1A5 (solute carrier family 1 member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc1a5 |
| Official Name | solute carrier family 1 (neutral amino acid transporter), member 5 [Source:MGI Symbol;Acc:MGI:105305] |
| Ensembl ID | ENSMUSG00000001918 |
| Bio databases IDs | |
| Aliases | solute carrier family 1 (neutral amino acid transporter), member 5 |
| Synonyms | AAAT, ASCT2, ATB(0), ATBO, H4-ASCT2, M7V1, M7VS1, R16, RDRC, Slc1a7, solute carrier family 1 member 5, solute carrier family 1 (neutral amino acid transporter), member 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc1a5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sodium:dicarboxylate symporter family
- signaling receptor activity
- channel/pore class transporter
- aspartate transporter
- glutamine transporter
- antiporter
- TcyP
- protein binding
- serine transporter
- amino acid transporter
- transporter
- neutral amino acid transporter
Pathways
Biological processes and signaling networks where the Slc1a5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- Alzheimer disease
- organismal death
- glioblastoma
- glioblastoma cancer
- colon adenocarcinoma
- colon epithelial cancer
- hereditary spastic paraplegia
- abdominal aortic aneurysm
role in cell
- expression in
- growth
- apoptosis
- proliferation
- activation in
- colony formation by
- phosphorylation in
- cell viability
- migration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cellular membrane
- basal bodies
- centrosome
- basal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc1a5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glutamine transport
- viral entry into host cell
- erythrocyte differentiation
- neutral amino acid transport
- L-serine transport
- glutamine secretion
- protein homotrimerization
- amino acid transport
Cellular Component
Where in the cell the gene product is active
- basal plasma membrane
- extracellular vesicular exosome
- melanosome
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- antiporter activity
- L-glutamine transmembrane transporter activity
- neutral amino acid transmembrane transporter activity
- signaling receptor activity
- L-serine transmembrane transporter activity
- symporter activity
- L-aspartate transmembrane transporter activity
- amino acid transmembrane transporter activity
- ligand-gated channel activity
- protein binding
- metal ion binding
- viral receptor activity