Chek1 Gene Summary [Mouse]
Enables histone H3T11 kinase activity. Involved in negative regulation of gene expression, epigenetic. Acts upstream of or within several processes, including DNA damage checkpoint signaling; G2/M transition of mitotic cell cycle; and inner cell mass cell proliferation. Located in chromatin; nucleus; and replication fork. Is expressed in several structures, including adrenal medulla; brain; early conceptus; gonad; and gut. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human CHEK1 (checkpoint kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chek1 |
| Official Name | checkpoint kinase 1 [Source:MGI Symbol;Acc:MGI:1202065] |
| Ensembl ID | ENSMUSG00000032113 |
| Bio databases IDs | |
| Aliases | checkpoint kinase 1 |
| Synonyms | checkpoint kinase 1, CHK1, OZEMA21, rad27 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chek1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein Kinases, catalytic domain
- protein domain specific binding
- enzyme
- protein binding
- Protein kinase domain
- phosphorylation site
Pathways
Biological processes and signaling networks where the Chek1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- breast carcinoma
- neoplasia
- cancer
- T acute lymphoblastic leukemia
- organismal death
- oocyte/zygote/embryo maturation arrest 21
- tumorigenesis
- alveolar rhabdomyosarcoma
- soft tissue sarcoma cancer
role in cell
- expression in
- proliferation
- accumulation in
- differentiation
- phosphorylation in
- quantity
- apoptosis
- survival
- growth
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- centrosome
- cytosol
- nuclear foci
- chromosome
- nucleoplasm
- synaptonemal complexes
- telomeres
- chromatin
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chek1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle G2/M transition DNA damage checkpoint
- DNA repair
- replicative senescence
- DNA replication
- signal transduction in response to DNA damage
- positive regulation of cell cycle
- protein phosphorylation
- chromatin remodeling
- G2/M transition of mitotic cell cycle
- apoptotic process
- cellular response to caffeine
- negative regulation of DNA biosynthetic process
- negative regulation of mitosis
- negative regulation of gene expression, epigenetic
- response to DNA damage stimulus
- nucleus organization
- regulation of cell proliferation
- regulation of mitotic centrosome separation
- DNA damage checkpoint
- cellular response to mechanical stimulus
- inner cell mass cell proliferation
- regulation of double-strand break repair via homologous recombination
- negative regulation of G0 to G1 transition
- peptidyl-threonine phosphorylation
Cellular Component
Where in the cell the gene product is active
- chromatin
- condensed nuclear chromosome
- nucleoplasm
- replication fork
- chromosome, telomeric region
- nucleus
- centrosome
- extracellular space
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein domain specific binding
- protein binding
- protein kinase activity
- protein serine/threonine kinase activity
- histone kinase activity (H3-T11 specific)