Rusc1 Gene Summary [Mouse]
Enables actin binding activity. Predicted to be involved in protein polyubiquitination. Located in Golgi apparatus; early endosome; and microtubule cytoskeleton. Is expressed in gut; nervous system; and sensory organ. Orthologous to human RUSC1 (RUN and SH3 domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rusc1 |
| Official Name | RUN and SH3 domain containing 1 [Source:MGI Symbol;Acc:MGI:1919546] |
| Ensembl ID | ENSMUSG00000041263 |
| Bio databases IDs | |
| Aliases | RUN and SH3 domain containing 1 |
| Synonyms | 2210403N08RIK, LOC100360417, NESCA, RUN and SH3 domain containing 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rusc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- domain involved in Ras-like GTPase signaling
- actin binding
- leucine zipper domain
- protein binding
- RUN domain
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- Golgi Apparatus
- cytosol
- nuclear envelope
- early endosomes
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rusc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyubiquitination
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- nucleus
- microtubule cytoskeleton
- early endosome
- cytoplasmic vesicle
- cytosol
- Golgi apparatus
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding