Tes Gene Summary [Mouse]
Predicted to enable zinc ion binding activity. Predicted to be involved in negative regulation of cell population proliferation. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; embryo mesenchyme; and metanephros. Human ortholog(s) of this gene implicated in childhood acute lymphocytic leukemia; gastrointestinal system cancer (multiple); high grade glioma; lung non-small cell carcinoma; and uterine cancer (multiple). Orthologous to human TES (testin LIM domain protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tes |
| Official Name | testin LIM domain protein [Source:MGI Symbol;Acc:MGI:105081] |
| Ensembl ID | ENSMUSG00000029552 |
| Bio databases IDs | |
| Aliases | testin LIM domain protein |
| Synonyms | D6Ertd352e, LOC500040, Tes1, Tes2, TESS, TESS-2, testin2, testin LIM domain protein |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tes often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- PET domain
- protein binding
- PET (Prickle Espinas Testin)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- epithelial cancer
- epithelial neoplasia
- gastrointestinal neoplasia
- cancer
- neoplasia
- COVID-19
- atrial fibrillation
role in cell
- proliferation
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- Cytoplasm
- focal adhesions
- Nucleus
- cytosol
- membrane rafts
- filopodia
- filopodial tip
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tes gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- focal adhesion
- cytosol
- cell junction
- macromolecular complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- RNA binding
- protein binding
- cadherin binding