Vezt Gene Summary [Mouse]
This gene encodes a transmembrane protein that is essential for the formation of adherens junctions. It is required for both the pre-implantation morphogenesis of a blastocyst and for the implantation process. The encoded protein is also a component of the ankle-link complex in cochlear hair cells, where it may effect resilience to sound trauma. It is also thought to be involved in dendritic spine morphogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Details
| Type | Protein Coding |
| Official Symbol | Vezt |
| Official Name | vezatin, adherens junctions transmembrane protein [Source:MGI Symbol;Acc:MGI:2143698] |
| Ensembl ID | ENSMUSG00000036099 |
| Bio databases IDs | |
| Aliases | vezatin, adherens junctions transmembrane protein |
| Synonyms | A630071D13Rik, DKFZP434O158, VEZATIN, vezatin, adherens junctions transmembrane protein |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vezt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mysoin-binding motif of peroxisomes
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic spine
- mushroom spine
- glutaminergic synapse
- thorny excrescence
- Cytoplasm
- somatodendritic region
- postsynaptic region
- cellular membrane
- Nucleus
- cell-cell contacts
- cytosol
- stereocilia
- nucleoplasm
- dendritic spines
- dendritic spine head
- growth cone
- anchoring junction
- perikaryon
- dendrites
- cell-cell adherens junctions
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vezt gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- adherens junction
- acrosomal vesicle
- cytosol
- stereocilia ankle link complex
- stereocilium membrane
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- myosin binding