Sytl1 Gene Summary [Mouse]
Enables neurexin family protein binding activity. Involved in exocytosis. Located in melanosome and plasma membrane. Is expressed in several structures, including heart; liver; lung; metanephros; and spleen. Orthologous to human SYTL1 (synaptotagmin like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sytl1 |
| Official Name | synaptotagmin-like 1 [Source:MGI Symbol;Acc:MGI:1933365] |
| Ensembl ID | ENSMUSG00000028860 |
| Bio databases IDs | |
| Aliases | synaptotagmin-like 1 |
| Synonyms | 9030417L18, JFC1, LOC100505202, PSGL-1, SLP1, synaptotagmin-like 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sytl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- neurexin binding
- active site
- enzyme
- protein binding
- Slp homology domain
- Protein kinase C conserved region 2 (CalB)
- C2 domain
- Rab27 binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- prostate cancer
- prostatic carcinoma
role in cell
- quantity
- accumulation in
- accumulation
- abnormal morphology
- exocytosis by
- release
- clustering
- exocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma membrane fraction
- insulin granule
- cellular membrane
- Nucleus
- Plasma Membrane
- vesicles
- granules
- cytosol
- melanosomes
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sytl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intracellular protein transport
- exocytosis
Cellular Component
Where in the cell the gene product is active
- exocytic vesicle
- microvillus membrane
- extracellular vesicular exosome
- melanosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- neurexin family protein binding
- small GTPase binding