Patl1 Gene Summary [Mouse]
Predicted to enable RNA binding activity and translation repressor activity. Predicted to be involved in P-body assembly and deadenylation-dependent decapping of nuclear-transcribed mRNA. Predicted to act upstream of or within negative regulation of translation. Predicted to be located in cytoplasmic ribonucleoprotein granule and cytosol. Predicted to be part of CCR4-NOT complex. Predicted to be active in P-body. Is expressed in heart; male reproductive gland or organ; metanephros; and pancreas. Orthologous to human PATL1 (PAT1 homolog 1, processing body mRNA decay factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Patl1 |
| Official Name | protein associated with topoisomerase II homolog 1 (yeast) [Source:MGI Symbol;Acc:MGI:2147679] |
| Ensembl ID | ENSMUSG00000046139 |
| Bio databases IDs | |
| Aliases | protein associated with topoisomerase II homolog 1 (yeast) |
| Synonyms | hPat1b, Pat1b, PAT1 homolog 1, processing body mRNA decay factor, protein associated with topoisomerase II homolog 1 (yeast), RGD1305514 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Patl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- translation repressor
- protein binding
- single-stranded RNA binding
- translation regulator
- RNA binding
- poly(U) binding protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- GW body
- cytoplasmic ribonucleoprotein granule
- cytoplasmic mRNA processing body
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Patl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoplasmic mRNA processing body assembly
- deadenylation-dependent decapping of nuclear-transcribed mRNA
Cellular Component
Where in the cell the gene product is active
- PML body
- nuclear speck
- cytosol
- cytoplasmic mRNA processing body
- CCR4-NOT complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- poly(G) RNA binding
- poly(U) RNA binding