Tmem258 Gene Summary [Mouse]
Enables oligosaccharyltransferase complex binding activity. Acts upstream of or within several processes, including epithelial cell apoptotic process; protein N-linked glycosylation; and response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be part of oligosaccharyltransferase complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human TMEM258 (transmembrane protein 258). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmem258 |
| Official Name | transmembrane protein 258 [Source:MGI Symbol;Acc:MGI:1916288] |
| Ensembl ID | ENSMUSG00000036372 |
| Bio databases IDs | |
| Aliases | transmembrane protein 258 |
| Synonyms | 1810006K21Rik, C11orf10, Kud, Kuduk, RGD1560328, transmembrane protein 258 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmem258 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- Oligosaccharyltransferase subunit 5
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- rheumatoid arthritis
- aortic stenosis
- nasal polyp
- asthma
- major depression
- Crohn disease
- refractive error
- venous thromboembolism
- lipoprotein lipase deficiency
regulated by
- beta-estradiol
- trichostatin A
- CD 437
- valproic acid
- ST1926
role in cell
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmem258 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- protein N-linked glycosylation
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- oligosaccharyltransferase complex
- endoplasmic reticulum membrane
- cytoplasm
- membrane
- macromolecular complex
- endoplasmic reticulum
- oligosaccharyltransferase I complex
- membrane-bounded organelle
Molecular Function
What the gene product does at the molecular level
- protein binding