Psme1 Gene Summary [Mouse]
Contributes to endopeptidase activator activity. Acts upstream of or within antigen processing and presentation of exogenous antigen. Predicted to be part of proteasome activator complex. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in several structures, including adipose tissue; alimentary system; eye; genitourinary system; and hemolymphoid system gland. Orthologous to human PSME1 (proteasome activator subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psme1 |
| Official Name | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) [Source:MGI Symbol;Acc:MGI:1096367] |
| Ensembl ID | ENSMUSG00000022216 |
| Bio databases IDs | |
| Aliases | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) |
| Synonyms | 11S PROTEASOME alpha subunit, 11S PROTEASOME α subunit, HEL-S-129m, IFI5111, PA28A, PA28alpha, Pa28 α, protease (prosome) 28 subunit, alpha, protease (prosome) 28 subunit, α, Proteasome activator pa28 alpha subunit, Proteasome activator pa28 α subunit, proteasome activator subunit 1, Proteasome (prosome, macropain) 28 subunit, alpha, Proteasome (prosome, macropain) 28 subunit, α, proteasome (prosome, macropain) activator subunit 1 (PA28 alpha), proteasome (prosome, macropain) activator subunit 1 (PA28 α), REGalpha |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Psme1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- enzyme regulator activity
- protease activator
- Proteasome activator pa28 beta subunit
- Proteasome activator pa28 alpha subunit
Pathways
Biological processes and signaling networks where the Psme1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Psme1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of proteasomal protein catabolic process
- regulation of G1/S transition of mitotic cell cycle
- antigen processing and presentation of exogenous antigen
- positive regulation of endopeptidase activity
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
- proteasome complex
- proteasome activator complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- endopeptidase activator activity
- protein binding