Hacd3 Gene Summary [Mouse]
Predicted to enable enzyme binding activity and very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity. Involved in negative regulation of intracellular signal transduction. Acts upstream of or within JNK cascade and Rho protein signal transduction. Predicted to be located in endoplasmic reticulum and nuclear membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including adrenal gland; central nervous system; gonad; retina; and tibialis anterior. Orthologous to human HACD3 (3-hydroxyacyl-CoA dehydratase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hacd3 |
| Official Name | 3-hydroxyacyl-CoA dehydratase 3 [Source:MGI Symbol;Acc:MGI:1889341] |
| Ensembl ID | ENSMUSG00000033629 |
| Bio databases IDs | |
| Aliases | 3-hydroxyacyl-CoA dehydratase 3 |
| Synonyms | 3-hydroxyacyl-CoA dehydratase 3, 4930523M17RIK, B-IND1, Butyrate induced transcript 1, Hcad3, HSPC121, PTPLAD1, RGD1565496 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hacd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3-hydroxyacyl-CoA dehydratase
- alpha-crystallin Hsps/p23-like
- enzyme binding
- GTPase activator
- enzyme
- protein binding
- Protein tyrosine phosphatase-like protein, PTPLA
Pathways
Biological processes and signaling networks where the Hacd3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hacd3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Rac protein signal transduction
- small GTPase mediated signal transduction
- very long-chain fatty acid biosynthetic process
- JNK cascade
- fatty acid elongation
- Rho protein signal transduction
- I-kappaB kinase/NF-kappaB cascade
- positive regulation of viral genome replication
- positive regulation of viral protein levels in host cell
- sphingolipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear membrane
- focal adhesion
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- 3-hydroxyacyl-CoA dehydratase activity
- protein binding
- GTPase activator activity
- enzyme binding