Cnot1 Gene Summary [Mouse]
Predicted to enable armadillo repeat domain binding activity; molecular adaptor activity; and nuclear receptor binding activity. Predicted to contribute to poly(A)-specific ribonuclease activity. Involved in regulation of stem cell population maintenance and trophectodermal cell differentiation. Located in P-body. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Vissers-Bodmer syndrome and holoprosencephaly 12. Orthologous to human CNOT1 (CCR4-NOT transcription complex subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cnot1 |
| Official Name | CCR4-NOT transcription complex, subunit 1 [Source:MGI Symbol;Acc:MGI:2442402] |
| Ensembl ID | ENSMUSG00000036550 |
| Bio databases IDs | |
| Aliases | CCR4-NOT transcription complex, subunit 1 |
| Synonyms | 6030411K04RIK, AD-005, CCR4-NOT transcription complex subunit 1, CCR4-NOT transcription complex, subunit 1, CDC39, D830048B13, HPE12, KIAA1007, NOT1, NOT1H, RGD1308009, VIBOS, XSG13 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cnot1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCR4-NOT transcription complex subunit 1 CAF1-binding domain
- poly(A)-specific ribonuclease
- CCR4-NOT transcription complex subunit 1 HEAT repeat
- retinoic acid receptor binding
- CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819
- protein domain specific binding
- enzyme
- CCR4-NOT transcription complex subunit 1 TTP binding domain
- protein binding
- estrogen receptor binding
- CCR4-Not complex component, Not1
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- hereditary disorder
- Vissers-Bodmer syndrome
- alopecia-mental retardation syndrome type 4
- tumorigenesis
- holoprosencephaly 12 with or without pancreatic agenesis
- mental retardation
- complex neurodevelopmental disorder
- non-small cell lung cancer
role in cell
- differentiation
- transformation
- capivasertib resistance
- assembly
- translation in
- induction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic mRNA processing body
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cnot1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of mRNA catabolic process
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- gene silencing by miRNA
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
- nuclear-transcribed mRNA poly(A) tail shortening
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of cytoplasmic mRNA processing body assembly
- negative regulation of retinoic acid receptor signaling pathway
- regulation of stem cell maintenance
- negative regulation of intracellular estrogen receptor signaling pathway
- trophectodermal cell differentiation
- negative regulation of translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- membrane
- cytosol
- cytoplasmic mRNA processing body
- CCR4-NOT core complex
- CCR4-NOT complex
Molecular Function
What the gene product does at the molecular level
- poly(A)-specific ribonuclease activity
- protein domain specific binding
- protein binding
- RNA binding
- armadillo repeat domain binding
- estrogen receptor binding
- retinoic acid receptor binding
- binding, bridging