Prkacb Gene Summary [Mouse]
Enables ATP binding activity; cAMP-dependent protein kinase activity; and magnesium ion binding activity. Involved in protein phosphorylation. Acts upstream of or within negative regulation of smoothened signaling pathway; neural tube development; and regulation of protein processing. Located in ciliary base. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; liver and biliary system; and nervous system. Orthologous to human PRKACB (protein kinase cAMP-activated catalytic subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prkacb |
| Official Name | protein kinase, cAMP dependent, catalytic, beta [Source:MGI Symbol;Acc:MGI:97594] |
| Ensembl ID | ENSMUSG00000005034 |
| Bio databases IDs | |
| Aliases | protein kinase, cAMP dependent, catalytic, beta |
| Synonyms | beta-CATALYTIC subunit of PKA, CAFD2, Cat Beta, Cat β, CbPKA, PKACB, PKA C-beta, PKA C-β, Prkacb predicted, protein kinase cAMP-activated catalytic subunit beta, protein kinase cAMP-activated catalytic subunit β, protein kinase, cAMP dependent, catalytic, beta, protein kinase, cAMP dependent, catalytic, β, β-CATALYTIC subunit of PKA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prkacb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- protein serine/threonine kinase
- cAMP-dependent protein kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein tyrosine and serine/threonine kinase
- ATP binding
- protein binding
- magnesium ion binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Extension to Ser/Thr-type protein kinases
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Prkacb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Amyloid Processing
- Apelin Adipocyte Signaling Pathway
- Apelin Pancreas Signaling Pathway
- BMP signaling pathway
- Calcium Signaling
- CDK5 Signaling
- Corticotropin Releasing Hormone Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine Receptor Signaling
- Endocannabinoid Developing Neuron Pathway
- eNOS Signaling
- Ephrin A Signaling
- Glucocorticoid Receptor Signaling
- Gαi Signaling
- IL-1 Signaling
- Leptin Signaling in Obesity
- Melanocyte Development and Pigmentation Signaling
- Myc Mediated Apoptosis Signaling
- Netrin Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- NF-κB Signaling
- P2Y Purinergic Receptor Signaling Pathway
- Phototransduction Pathway
- PXR/RXR Activation
- Sonic Hedgehog Signaling
- Tight Junction Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- Alzheimer disease
- dry eye syndrome
- epithelial cancer
- septic shock
- type II collagen-induced arthritis
- acinar-cell carcinoma
- neoplastic cell transformation
- cardioacrofacial dysplasia type 2
- breast carcinoma
role in cell
- phosphorylation in
- transactivation in
- apoptosis
- proliferation
- survival
- transformation
- quantity
- assembly
- potentiation
- specification
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- perinuclear region
- Nucleus
- centrosome
- cytosol
- nucleoplasm
- neurites
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prkacb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- high-density lipoprotein particle assembly
- renal water homeostasis
- neural tube closure
- signal transduction
- protein kinase A signaling cascade
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- protein phosphorylation
- negative regulation of smoothened signaling pathway
- regulation of protein processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- extracellular vesicular exosome
- cytosol
- plasma membrane
- cAMP-dependent protein kinase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- ubiquitin protein ligase binding
- AMP-activated protein kinase activity
- protein binding
- cAMP-dependent protein kinase activity
- protein serine/threonine kinase activity