Acaa2 Gene Summary [Mouse]
Predicted to enable acetyl-CoA C-acetyltransferase activity and fatty acyl-CoA hydrolase activity. Predicted to be involved in several processes, including cellular response to hypoxia; fatty acid beta-oxidation; and negative regulation of mitochondrial membrane permeability. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; brain; integumental system; sensory organ; and urinary system. Orthologous to human ACAA2 (acetyl-CoA acyltransferase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acaa2 |
| Official Name | acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) [Source:MGI Symbol;Acc:MGI:1098623] |
| Ensembl ID | ENSMUSG00000036880 |
| Bio databases IDs | |
| Aliases | acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) |
| Synonyms | 0610011L04Rik, 3-ketoacyl coa thiolase, acetyl-CoA acyltransferase 2, D18Ertd240e, DSAEC, T1, THIOLASE |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Acaa2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thiolase, N-terminal domain
- 3-oxoadipyl-CoA thiolase
- cond_enzymes
- acetyl-CoA C-acyltransferase
- acetyl-CoA acetyltransferases
- fatty oxidation complex, beta subunit FadA
- acetyl-CoA C-acetyltransferase
- Thiolase, C-terminal domain
- enzyme
- Beta-ketoacyl synthase, C-terminal domain
- protein binding
- acyl-CoA hydrolase
Pathways
Biological processes and signaling networks where the Acaa2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- non-insulin-dependent diabetes mellitus
- polycystic kidney disease
- hepatocellular carcinoma
- mucopolysaccharidosis type IVB
- hepatic injury
- diabetes mellitus
- idiopathic scoliosis
- early onset hypertension
regulates
- fatty acid
- acetyl-coenzyme A
- 3-oxoacyl-coenzyme A
- ACAA2
role in cell
- proliferation
- migration
- invasion by
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- basal bodies
- Mitochondria
- mitochondrial membrane
- mitochondrial matrix
- nuclear bodies
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Acaa2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty acid beta-oxidation
- cholesterol biosynthetic process
- cellular response to hypoxia
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- acetyl-CoA C-acetyltransferase activity
- acetyl-CoA hydrolase activity
- RNA binding
- protein binding
- acetyl-CoA C-acyltransferase activity
- acyl-CoA hydrolase activity