Cdk8 Gene Summary [Mouse]
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Part of mediator complex. Is expressed in embryo; tibialis anterior; and tongue. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human CDK8 (cyclin dependent kinase 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Cdk8 |
| Official Name | cyclin-dependent kinase 8 [Source:MGI Symbol;Acc:MGI:1196224] |
| Ensembl ID | ENSMUSG00000029635 |
| Bio databases IDs | |
| Aliases | cyclin-dependent kinase 8 |
| Synonyms | cyclin-dependent kinase 8, IDDHBA, K35, LOC100360585, RGD1560888, SRB10 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cdk8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- protein kinase
- Protein Kinases, catalytic domain
- alcohol group acceptor phosphotransferase
- ubiquitin protein ligase activity
- protein binding
- Protein kinase domain
- activation loop
Pathways
Biological processes and signaling networks where the Cdk8 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- intellectual developmental disorder with hypotonia and behavioral abnormalities
- glioblastoma
- glioblastoma cancer
- pituitary gland adenoma
- head and neck neuroendocrine neoplasia
- organismal death
- complex neurodevelopmental disorder with or without congenital anomalies
- allergic rhinitis
role in cell
- phosphorylation in
- proliferation
- apoptosis
- expression in
- growth
- survival
- self-renewal capacity
- K48 polyubiquitination in
- transport in
- recruitment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- nucleoli
- euchromatin compartments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cdk8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell cycle
- negative regulation of triglyceride metabolic process
- protein phosphorylation
- positive regulation of transcription from RNA polymerase II promoter
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- ubiquitin ligase complex
- mediator complex
- cyclin-dependent protein kinase holoenzyme complex
- macromolecular complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- RNA polymerase II carboxy-terminal domain kinase activity
- protein kinase activity
- cyclin-dependent protein kinase activity
- protein serine/threonine kinase activity