Il22ra1 Gene Summary [Mouse]
Enables interleukin-20 binding activity and interleukin-22 receptor activity. Involved in negative regulation of inflammatory response. Acts upstream of or within defense response to Gram-negative bacterium and negative regulation of cytokine production involved in inflammatory response. Predicted to be active in plasma membrane. Is expressed in ileum. Orthologous to human IL22RA1 (interleukin 22 receptor subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il22ra1 |
| Official Name | interleukin 22 receptor, alpha 1 [Source:MGI Symbol;Acc:MGI:2663588] |
| Ensembl ID | ENSMUSG00000037157 |
| Bio databases IDs | |
| Aliases | interleukin 22 receptor, alpha 1 |
| Synonyms | 9130219A07Rik, CRF2-9, IL-22R, IL22R1, interleukin 22 receptor, alpha 1, interleukin 22 receptor subunit alpha 1, interleukin 22 receptor subunit α 1, interleukin 22 receptor, α 1, RGD1559655 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Il22ra1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- interferon receptor
- extracellular domain
- cytoplasmic domain
- FN3
- protein binding
- interleukin-22 receptor
- Tissue factor
- transmembrane receptor
- interleukin-20 binding
Pathways
Biological processes and signaling networks where the Il22ra1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- psoriasis
- gastric adenocarcinoma
- gastric epithelial cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- renal cell cancer
role in cell
- activation in
- expression in
- phosphorylation in
- proliferation
- production in
- quantity
- differentiation
- extravasation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Il22ra1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- defense response to Gram-negative bacterium
- cytokine-mediated signaling pathway
- negative regulation of inflammatory response
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- interferon receptor activity
- interleukin-20 binding
- cytokine receptor activity
- interleukin-22 receptor activity