IL22RA1 Gene Summary [Human]
The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IL22RA1 |
| Official Name | interleukin 22 receptor subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:13700] |
| Ensembl ID | ENSG00000142677 |
| Bio databases IDs | |
| Aliases | interleukin 22 receptor subunit alpha 1 |
| Synonyms | 9130219A07Rik, CRF2-9, IL-22R, IL22R1, interleukin 22 receptor, alpha 1, interleukin 22 receptor subunit alpha 1, interleukin 22 receptor subunit α 1, interleukin 22 receptor, α 1, RGD1559655 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IL22RA1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- interferon receptor
- extracellular domain
- cytoplasmic domain
- FN3
- protein binding
- interleukin-22 receptor
- Tissue factor
- transmembrane receptor
- interleukin-20 binding
Pathways
Biological processes and signaling networks where the IL22RA1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- psoriasis
- gastric adenocarcinoma
- gastric epithelial cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- renal cell cancer
role in cell
- activation in
- expression in
- phosphorylation in
- proliferation
- production in
- quantity
- differentiation
- extravasation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IL22RA1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- defense response to Gram-negative bacterium
- cytokine-mediated signaling pathway
- negative regulation of inflammatory response
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- interferon receptor activity
- interleukin-20 binding
- cytokine receptor activity
- interleukin-22 receptor activity