Tra2a Gene Summary [Mouse]
Enables identical protein binding activity. Acts upstream of or within positive regulation of mRNA splicing, via spliceosome. Located in nucleus. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; olfactory epithelium; and retina. Orthologous to human TRA2A (transformer 2 alpha homolog). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tra2a |
| Official Name | transformer 2 alpha [Source:MGI Symbol;Acc:MGI:1933972] |
| Ensembl ID | ENSMUSG00000029817 |
| Bio databases IDs | |
| Aliases | transformer 2 alpha |
| Synonyms | 1500010G04RIK, AWMS1, G430041M01RIK, HSU53209, mAWMS1, RGD1562563, TRA-2 alpha, TRA-2 α, TRANSFORMER-2 alpha, transformer 2 alpha homolog, TRANSFORMER-2 α, transformer 2 α homolog |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tra2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- arginine serine dipeptide repeat domain
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- protein binding
- identical protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- serous ovarian adenocarcinoma
- serous ovarian cancer
- pancreatic cancer
- schizophrenia
role in cell
- growth
- splicing by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tra2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of nuclear mRNA splicing, via spliceosome
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- intracellular membrane-bounded organelle
- spliceosomal complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding